I am not really the one to be giving advices but here is my take so far. I too have seen Mirai's great tutorials and how powerfull ISboxer is using macros. But all in all, so far I have used Mercurio's method and applying to my class and skills on the Macro library's Post mentioned on the first page. Basically you just order them up on what skills to prioritize in a sequence without using complicated castsequence.

I am still in the 70s but my Hunter were doing horrendous DPS using hard coded castsequence macro. I tried out Mercurio's Marksman's Macros and applied to my team and now they do about 4 times more damage. I am sure macros will deal with more micro management and one day would like to see them in action in my teams. But its a start, have a try.

P.S. I am having a little trouble with my Warrior tank since everything is instant cast and a lot of proc going on, some skills will miss opportunities when procced.