Whatever it is that is happening, does not sound to me like it is from ISBoxer. ISBoxer has no function to minimize the window (it can swap between Active and Home Region) and cannot switch to a non-ISBoxer window unless you've got an "Other window source" from a Video FX and activate the Video FX Focus Hotkey while the mouse cursor is over a Viewer for that source. So unless you've set the Video FX Focus Hotkey to Tab in your Character Set, and have a Video FX Viewer and a currently-active "Other window source" (you would have had to specifically open up the ISBoxer Control Panel in game, and configure an Other Window Source, since launching the game. There's probably a 0.00001% chance you did this.)
Alt+Tab and Shift+Alt+Tab are Windows Hotkeys; ISBoxer doesn't send keys to Windows, just to the game. If you have ISBoxer press Alt+Tab, it's not going to switch windows, and if you have ISBoxer hold Alt while you press Tab, it's also not going to switch windows. That is, unless the game has something built into it to accept that particular Hotkey and do something as a result.
IMHO this is happening because of other software installed on your PC. If you have not rebooted recently, I might suggest doing that to help clear up anything weird...
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