I think everyone has made some very good points in this discussion..

the things that you need to think about.
1. do i want to spend/devote time just on setting up?
2. do i have the technical knowledge to teach myself how to set up the program?
3. can i afford/willing to pay for it?

I personally went for keyclone as the easiest way to multibox (IMHO) and have been quite happy with it.. but you need to decide what fits best for you.