The only time multiboxing in PvP works is like Mosg2 stated. You simplify everything and overload as much burst potential as possible to one shot your way to victory. You do that or you put some serious numbers in your favor and do pointless things like hang around vendors and blow up people in green starter gear. Either way its an unsupported way to play the game that feels and is bottom feeding at a premium. It makes little sense.

You'll never be competitive in a thinking match with 2 / 3 / 5 / 10 humans on the other side of the equation either.

I think the rationale for multiboxing PvP in an MMO starts with getting harassed by a couple guys in the world. Then you think man, if I had 2 or 3 more accounts I would have owned those guys. Then next time they see you, they bring a 5 man team. The arms race mentality goes like that.

Once I stopped multiboxing WoW I oddly started to enjoy it more. Yes, I still ran into those griefers out in the world while soloing but I'm no longer inclined to renew any additional subs because it will be a short-lived satisfaction. I got my 9/9 golds done in like 3 days, got my garry achievement and started to gear up a single toon WAY faster. It just feels like I'm doing a lot less screwing around with setup and more socializing / more progress.

As a multiboxer who went back as far as EQ / MQ my days of mutiboxing are almost certainly over. If it wasn't the overly complicated routines needed for WoW it was the fact that I was paying 5 times as much for half the progress most were making on a single toon. It just didn't add up.

PS: I don't think they will ever remove IWT / CTM as it would raise a serious stink regarding accessibility for handicapped people.