The majority of games ignore at least some input unless they are the foreground window. I don't know about Drakensang Online specifically off the top of my head, but if that's one of the games with this limitation it's simply not going to work at all with Pwnboxer. The problem would be exactly as you have described -- key and mouse broadcasting do nothing. If this is the case, it will also not work with Keyclone, HotkeyNet, Pwnboxer, or any other multiboxing software of that class; On the other hand, ISBoxer does support Drakensang Online.
This is also kinda a double whammy question. Drakensang Online is not typically discussed here, and Pwnboxer support is pretty much non-existent. It's almost exclusively designed for World of Warcraft, and people have been having trouble getting it to work even with WoW. I mean, have you checked the official Pwnboxer forum? Total ghost town, customers asking for support and refunds but no support to be found.
Good luck
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