The following assumes you use innerspace / isboxer:
Some combinations are not ideal for a multiboxer because of how the classes themselves work.
For example an affliction lock is best paired with other dot-splashing classes like DKs so tabbing around to multiple targets doesn't hurt DPS.
Others like WAR + HUNT are a very good combo for single target approaches because they both optimize single target burst.
Then you have the defensive stuff. A lock + DK team has amazing AoE CC with shadowfury and endless winter. Other teams can't compare to it.
To control multiple classes you have to pin down the commonalities that all classes have in common. Such as cooldowns. All cooldowns range from <= 2m to 3m to 5m and even 10m. You can then setup macros in the WoW helper to handle cooldowns across multiple action groups, ex:
Originally Posted by My 10m cooldown group - has everything
Originally Posted by My 2m cooldown group - has much less
You can take it further by grouping up stuns, interrupts and snares:
!if (character is in "Hunter") /cast Intimidation
!if (character is in "Warrior") /cast Shockwave
!if (character is in "Shaman") /cast Frost Shock
!if (character is in "Hunter") /cast Concussive Shot
!if (character is in "Warrior") /cast Hamstring
!if (character is in "Shaman") /cast Frost Shock
!if (character is in "Hunter") /cast Silencing Shot
!if (character is in "Warrior") /cast Pummel
!if (character is in "Shaman") /cast Wind Shear
Then, with those macros you setup a round robin approach and cap the steps at a reasonable number so they don't overlap too much or take too long in your keypress rotations.
Ideally you want to consolidate as much as possible. The Lazy Macros site is an excellent resource for consolidating sequences and randoms per class / spec. Then with some practice inside isboxer you can handle a decent class / spec spread.
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