I wouldn't consider C5 sub-cap sites to be a decent replacement for running high sec incursions. A whole lot more risk, a whole lot more effort of scanning/scouting, and the cloaky proteus hiding behind every planet.

I haven't had the chance to run escalations yet, but I think they'd be what your looking for, if you were looking for more ISK/hr per character, albeit with a serious increase in risk.