Quote Originally Posted by Knytestorme View Post
My understanding with ISBoxer is that it renders all the pixels for the resolution you're going to play at and then scales down to the actual screen size displayed...eg if I'm playing at 1080p with 5 clients it will render 5 clients at 1080p and then scales the size down to 1/2 screen per clients outside the main that runs at full screen.

If this is correct (and am sure Lax, Mirai or someone else can correct me if I'm wrong) then whether I run 5 panels at 1080p or 2 panels with 5 x 1080p clients it makes no difference in terms of pixels being rendered.
Assuming you have Instant Swapping enabled, then this is correct.