I've been in the closed alpha since the Friends and Family stage (I got bro's that work at Trion). I've posed some tentative questions about Hackshield but have heard nothing back. Isboxer absolutely does not work currently. Other than that, the game is absolutely perfect for multiboxing. It has autofollow, it has the requirements for assisting, it has click to move (would make melee teams work fine because you will auto run into range/face the target to use a skill).

I know that people CAN box this game with keyclone but I personally haven't run Keyclone since probably 2006 (before I found ISboxer) and after the ease of use and flexibility of ISboxer I don't think I could bring myself to work with Keyclone. If anyone does the legwork for keyclone though by all means post your settings up please! ;p