One of the big things you will want to know is if you plan to plex or pay irl iskies for your character's accounts. Mining is nice in that it scales in a linear fashion and is low input but its also very high risk in null with the interceptor changes. Beyond that everyone and their mother will be dicking about with the nullsec indy changes; don't bet too quickly that the miner will make the most isk. In general i would say the middlemen doing the compression will.