I'm running 5 clients on a 4930k @ 2560x1600 plus a second monitor at 1920x1200 using a EVGA 780 Ti Classified and I get stuttering when moving the camera around. It's bad enough that I reduced the resolution on the main monitor to 1920x1200, which makes the whole rig run solidly at 60fps on the master and 30fps on the slaves. So I'd agree, 5 clients at 2560x1600 on *any* current hardware (WoW) would be a problem.
(My best guess is that the 3GB vram is the bottleneck. If the 6GB 780 ti comes out it may change everything.)
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