Well, first of all, what is your UI? It is very nice.

I use Healium for my healer, then put a VideoFX overlay on it and sync it to everyone else. No keybinds needed. It shows your party list and spells you can click on them next to their name. I love it.

For everyone else, I basically use 1 for single target dps, and 2 for aoe. Maybe another key if I need totems, traps, or whatever.

I use a G600 mouse with the side keys acting as numpad keys. I save those for the class that's playing tank at the moment. Only use a few buttons on it so far, but when I need more keys, they are there.

Just picked up a Steelseries Merc Stealth keyboard for the left hand. I like it. Tried a Blackwidow Ultimate, a Nostromo and a G13 before. So, plenty of keys available to use when needed, but I only use a few for now.