I plan on having a central large (landscape format) monitor for the master toon and two smaller (portrait format) monitors -- one on each side for the slaves -- 5 toons altogether.

How do I wire that up? Do all three monitors get connected to the same GPU, assuming SLI? Or do you connect one to the central monitor and the other two to the other GPU?

Would I be better off without SLI, and drive the central monitor with one GPU and the other two monitors with the other GPU?