I didn't see it mentioned in this thread, but theCore for Starcraft II is built on principles that can be adapted to WoW. It shifts the hand so that the thumb is on Shift, rather than the pinky since that's the most frequently used key in Starcraft II. This means moving a right hander mouser's left hand over to the right side of the keyboard. They also adjust the home row position and tilt the keyboard. Overall the ability to easily thumb to 4 different modifier combinations (alt, shift, control, shift+control) expands the number of reachable abilities significantly.

theCore homepage: http://www.teamliquid.net/forum/view...opic_id=341878

I find the older outdated introductory videos better for getting a quick understanding.
Why the Core? http://www.youtube.com/watch?v=I4luxRv4ye0
Positioning http://www.youtube.com/watch?v=gj5Xj9LJKZQ also http://youtu.be/zbI1YMEXz98?t=3m40s

I use a Core inspired layout myself in WoW (single player shadow priest screenshot at bottom). My right hand rests on fghj, index to pinky. My movement keys are on my pinky at jkm, (forward, strafe right, strafe left, backwards). My thumb hits alt where healing and utility binds are mapped.

The layout is by no means optimal, there are some swaps I could do to improve it. (should shift leftward so my thumb can hit control and shift better, but I have plenty of binds with one modifier).

Sservis hotkeys.jpg