With the F keys I'm particularly picky about the keyboard, some them in rows of 5, shape is different or smaller. On the G510 (and others) they are in rows of 4 and easy to hit. They may not be the best bindings (I'm sure there's a modifier that may work better) but I've been using them since vanilla and muscle memory is good. F1-F4 are all related to combat (F1 being a offensive/defensive CD depending on context), F2-F3 being a DPS/Healing CD, and F4 being a major defensive CD (iBF, Shield Wall). F5 and F6 I don't consider good bindings but I use them army of the dead which I'll do standing still several seconds before entering combat.
I have key up/key down IWT on F1-F4 because I noticed slight runaways when I was say, using AMS while in combat, so in this case they'll AMS and continue another IWT towards my target, giving me time to move back down to 1-5 which are DPS keys. I ended up doing the same for a lot of things, like fear break (lichborne/tremor/etc.) - IWT on key up so when they break fear they start running back right away.
I never get big into modifiers and I don't know how long that takes to string.. I have I think shift 3, 4, and 5 and that's about it. I supposed shift could work well with R, T, Y, F, G, H, V also. But I still fat finger FTGYH without modifers as it is (trying to pop bloodlust/pillar/skull banner and hit panic heal rotation instead, or G which activates a virtual keymap that turtles the healers - rock guys, astral shift, healing on each other, hand of protection and such, and then the rest of the team gets no healing).
I never quite find a perfect keybind setup, and sometimes I settle for less than optimal ones and just get used to it and when I try to change to something else, things get sloppy. I used G for D&D and H for Unholy Blight 9 months ago and I still accidentally hit those and end up blowing tons of cooldowns. Those are now shift+3 and shift+4.
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