There's another way to hit CTRL? I guess it's my nails, but I've got no other way to hit CTRL without hitting every other button on the way down, lol.

I don't think I could ever switch to alternate movement keys. If I swapped to ESDF, Tab {my IWT key}, ~ {my IWM key} and CTRL all become hard to reach. Alt can be pushed down with the bottom segment of my ring finger, but since I've got a wedding ring there, I have no real sensation of pushing. It's much easier for me to simply fold my thumb under to hit ALT as I do on WASD. It also makes my hand rest on the left Windows key and Caps Lock, which are not keys I want to be tripping over all the time. It feels like a disaster for my carpel tunnel.

As far as the mouse, I think I use far more mouse buttons than I do keyboard buttons. It's just way easier for me to roll my thumb around than it is to reach around a keyboard. All those years with the Gameboy perhaps.