I've actually been using keyclone, it's worked pretty well for me. A couple of quirks and differences from WoW, but, hey, if you multibox you get used to dealing with quirks. Some of the functionality of the macro system is actually an improvement over WoW.

The launcher, I'm not using, I didn't want to bother figuring out how it do it, basically, with the Rift launcher and all. I start each Rift window, logging in through their launcher, then manually adding to keyclone using the add button on keyclone and clicking the Rift window to add. I would think that would preserve the start up settings if you have different installs.

The only crashes I'm seeing are Rift ones, usually while teleporting, getting the send the Rift error report message. I'm using the movement keys on all my characters, but set to DNP on keyclone. Using both mouse keys seems to work fine for movement for me.

I'm using three pretty different computers also. I'm using only keyclone and keyboard / mouse sharing software to play. I've played to level 40 so far. So I think it's safe to say there's no basic incompatibility between Rift - Keyclone - and various hardware and software.

I'd give a shot at manually launching and manually adding to keyclone, see if that helps.