Anomolies in null (not the scanned down anomolies, the 'public' anomolies) - used to do it with 5 x Navy Ravens (which was massive overkill tbh) but I've sold them and am swapping into Typhoons.
Warp in at 100km, chuck out Sentries, kill everything before it gets to about 60km, so never worry about scrambling/neuting etc etc.
I only use the cheap T1 cruise missiles, too, as I'm overkilling most targets and the price jump to T2 ammo is silly (you'd end up losing money on frigates and some cruisers).