I'll assume from your sig that you're talking about WoW?

Did you make sure you have the ISBoxer Addon enabled?

The only thing that should change regarding old profiles, is for people who previously configured a Hotkey in the Repeater Profile, Hotkeys page. The one that said "don't use this setting" is now gone and the Hotkeys removed. Configure Repeater Hotkeys in the Always On Key Map ("Control" in old WoW configs)

Regarding new teams, consider backing up your current profile and going with a fresh one, as much has changed. WoW used to use "General" "Control" and "FTL DPS Keys" key maps, now it uses the same names as all the other games ("Non-combat" "Always On" "Combat") and if you already had those Key Maps, they don't get modified with the new mappings