Its pretty rough to be able to pull 1-2 bil in a 1-3 hour setup. Closest you may get may be Incursions VGs. You could potentially make it running C3/C4 Sleeper sites, but there is a lot of more risk there than running VGs in highsec.

Incursion HQs take 20-40 people to do which is a bit rough on a Multiboxer with only 10-12 toons. I personally run 12 toons, primarily for running sleeper sites/industrial stuff. I own nullsec space for my small team as a renter, running the anoms in a Military 5 system very much sucks only 30-50 mil an hour. I could make more stripping the Grav belts with 10 toons.