Quote Originally Posted by Negativ1337 View Post
1) For my shamans I used the following macro in the past when I was using keyclone to heal my toons:
Heal main toon:
/cast [target=focus] Healing Wave
Heal main toon's target:
/cast [target=focustarget] Healing Wave
Because ISBoxer is focusless, leaderless and targetless, how can I heal my main toon/the target of main toon with 2 different keymaps/macro's?
Saying that ISBoxer's follow and assist are Focus-less just means that it doesn't require Focus to function correctly and you're free to do whatever you want with it. So, if you want to use a healing macro directed at your Focus, then by all means, use it.

Quote Originally Posted by Negativ1337 View Post
2) When I disable keymaps (Keymaps 'OFF') then my keymaps are still used. When I press 1 for example all my toons type in chat: ``1`` ( ` = IWT hotkey ). I just want them to type '1'.
Thanks in advance,
Kind regards,
Negativ1337
You'd need to share your config for a clear cut answer, but my guess is that you've created copies of the default Key Maps and they're not correctly toggling off/on because you didn't modify the Activate Maps Mapped Key to reflect those changes.