Getting the infusions with just two would be quite difficult. Putricide is a solid maybe, I go in there with 5, and sometimes still wipe on him in heroic, bloodqueen requires I think 7 to properly spread bites without everyone going nuts with the mind control. You could probably do Sindy since I don't think she freezes the main tank. I brought in outside help to get the infusions, then after that its a simple matter of killing bosses until you get the shards.

and yes, a single geared healer is more than enough for the healing boss.