You're not going to be able to swap regions between systems.
If you have six clients on a newer machine and four on the older one...
The six can likely swap between each other, but they cannot swap with the four.

Not sure how the mouse broadcasting is going to be across multiple systems.
If you have instant swap enabled, it is extremely accurate.
But you're not going to be able to instant swap across the machines.
You'd probably have to talk to Lax, or someone who boxes on multiple machines with IS Boxer.

There is a multiple computer forum, on the isboxer site.
Likely more information there.



I'd imagine FTL is going to work fine, between systems.
Everyone will have a unique modifier.
So anyone should assist any leader, without issues.

Other mapped keys should work, aside from possible issues with mouse broadcasting across systems.
Depending on how well mouse broadcasting works, you might want everyone who broadcasts the mouse on the main system.
That would be something to investigate.