I did this across 2-3 PCs in Octopus and now ISBoxer in multiple games. Basically, what I have/had set up is TAB key to turn on mouse broadcasting while pressed and turn off mouse broadcasting when released. Then when I have something I want to do with multi-toon clicks, I just hold down TAB and click away. Then when I release it, things go back to normal. Octopus and ISBoxer can both do this while not broadcasting any other keys so they should work fine with your setup.
The benefit to using ISBoxer/Octopus for mouse click broadcasting is that as long as all your game windows are set to the same aspect ratio, the clicks will be almost exactly accurate across all clients every time. With hardware mouse broadcasting, you have to "zero" the mouse to make sure the click is accurate.
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