I personally run 5box on my laptop *specs in sig*. I run 30fps on main window and abuse the shit out of PiPs and BOOBS with KeyClone. Runs without a hitch in PvE, they are still young though so they havn't been battle tested in PvP. I imagine that AV would be pretty ugly on framerates with lots of people on the screen though. Org turns into a move 10yards, wait 5seconds, move 10 yards, wait 5seconds deal.

Despite all its 'cons' if you don't have the financial means, or in my case no fucking room in your house to setup your desk and your 6PCs in storage, a mid-high end laptop can 5box just fine.