Most people software box.

Keyclone (www.solidice.com/keyclone) is $20 for a lifetime license.
You need one license per computer.
It has all of the basic features, but does not have a lot of the advanced features of other products.

Hot Key Net (www.hotkeynet.com) is free, which is always a good price.
This is script based, so you essentially need to write your own code (or modify the example script given).
HKN has most of the features of IS Boxer, if you're comfortable with the script nature of HKN.

IS Boxer (www.isboxer.com) is a subscription based option ($15/quarter; $50/year).
There are wizards to get you started, a detailed forum & wiki, and an IRC on its site.
Nothing really compares to IS Boxer, but HKN is the closest.

I would recommend one of these three options.
Numerous users on this site use all three, and the authors of each are quite helpful.

There are other options to consider, but none of the subscription based are as strong as IS Boxer... and HKN seems easier (or more documented) than AHK for the free options.