The "Pro" method makes a lot more sense, having looked at the CLS configuration.
I didn't really get it (variable mapped keys), from reading the wiki entry when I first took a look at it.

For some reason, my balance druids are doing IWT even though none of the toons are in a melee group.
As with any configuration, would need to tweak it a bit.
I like my melee IWT, in that if a toon is in the melee ATG they IWT as part of the combat spam but otherwise do not.

A lot of my hotkeys don't do anything, because they're not part of the configuration.
Most likely will go with a variation between the two, ending up hopefully with the methodology/organization of the Pro method, but with all my hotkeys doing what I expect them to do.