Typically, we multiple computer people use a multiboxing app for keys/clicks/cursor and something like InputDirector for controlling the other PC directly e.g. mousing over to the clients on the other PC.

Things you won't be able to do between PCs:

* Instant swap (can't swap clients between PCs)
* ISBoxer Video feeds (can show any feed on any clients as long as they're on the same PC)
* ISBoxer cursor broadcasting (this works but the 2nd PC won't pan as smoothly and there may be some issues if your clients aren't all the same resolution)

For the most part, everything else (clickbars, click broadcasting, mouseover heals, etc.) works exactly the same. This also applies to Keyclone, Octopus, HKN, Mojo, etc.