I did delete and remake and it did not do anything to help. This is what I discovered if while my runes are on cooldown or I am on a GCD from something in my cast sequence if I spam an instant like blood boil or horn of winter or something like that when my sequence advances to Heart Strike the cast sequence sticks. Let me iterate this. My sequence my run just fine 100 cycles in a row then if I spam an instant my sequence may do something like Icy Touch, Plague Strike, Death Strike perfectly fine then when it gets to Heart Strike it sits and spins. This is clearly some type of bug from the patch.