Over the bank holiday weekend I levelled up 3 x Monk and 1 Warrior to Inferno, Paragon level 2 - from creation- pretty much a difficult each day, I still did things like went to the Zoo so wasn't solidly playing.
I had 25% increased experience gems in my helms so that helped.
I guess as you've started now, you're able to answer your own questions
I play 4 x client at max settings and I get slowdown in the sewers, and occasionally when this new melee team have hundreds of spells firing off on a busy screen! Never was like that with the witch doctors.
I've now ticked the 'low particle' box I think it's helped.
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