I'm running something fairly close to yours. Love the UEFI of the Sabertooth. I'm a complete novice to OC'ing and the "Optimal" settings in the UEFI make it simple. Here's my rig:
CPU: i7 3770K
MOBO: Sabertooth Z77
RAM: GSkill RipJaws 1600Mhz 24GB (2x4GB; 2x8GB)
GFX: NVIDIA GeForce 570 GTX HD (drops between 30 and 40 FPS in the center of Org.)
HDD(s) Western Digi Caviar Blue 500gb (Win 7 and all my other files); Crucial M4 120gb SSD (games)
Heat Sink: Thermaltake Performer (closed loop water cooled)
Power: Corsair HX850
OS: Win7 64bit Pro
Case: Antec 900 Black Steel
I skimped in some places, but I didn't have $2000 to sink into it.
Had to do some tweaking to get the ASUS "Thermal radar" software working... the software package that came with the packaged with the motherboard was "unfriendly." Had to go to the ASUS site and download software from other motherboards to make it work. I was a little disappointed that the "EZ Tune" (easy overclocking) functionality was non-existent in the software package. "Fan Xpert" is really cool, though it doesn't control the chasis fans. CPU runs between 26c and 30c at 4.1gHz. Also I had to go in and change memory settings to 1600 manually because the UEFI originally only recognized the memory as 1333. The other cool software that came with the motherboard is "Network iControl" which lets me set priorities for all software that connects to internet. I'm really happy with the motherboard as a whole package.
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