I used to 4 box in everquest, with 2 comps, and 2 accounts on each and alt tabbing between accts. Had no software help, just manually performing all tasks on one toon at a time. Was slow, and not very effective, but it worked. When I tried 5 boxing WoW with keyclone on one pc it was alot easier, although when i 3 boxed on a pvp server that wasn't so good when someone got bored and decided to mess with me.