I have trouble with mouse sync since my main window is on 30" 2560x1600 monitor and the 4 others are on 1920x1080.

I have been trying out a 3x5 click bar setup. Line 1 cast a big heal (Healing Invocation) on marked targets 1 through 5. Line 2 does a little fact heal and line 3 does Ward of the Ancestors or Shield in the case of the cleric mark. I think I am going to set up a right click option to activate directed heals from the Chloro. The issue with the click bar has been I tend to use both hands on the keyboard to drive my group. Perhaps an improved mouse with addition buttons might be in order so I can continue to spam my DPS keys while moving the mouse to activate a off-heal. As it is I lose too much time reaching over to the mouse, finding the pointer, then clicking the appropriate button to trigger the heal.