On the Pally/DK team.

If I spam "1", the team does the Howling Blast, Necrotic Strike, Frost Strike, Death Coil sequence.
If I spam "2", the team does the Obliterate, Frost Strike sequence.
If I spam "6", the team does the Death Strike, Frost Strike sequence.

Spamming any of these, sends "1" and "2" to the Pally.
Which does nothing without a focus, but spams Flash of Light and does a Holy Shock x3, Word of Glory rotation with a Focus set.

I manually mouse heal on Grid, on the Pally's screen... plus select targets, for the DK's.
I use: Flash of Light, Divine Light, Holy Shock, Word of Glory, Cleanse and Holy Radiance.
Scroll Wheel up, sets a focus; Scroll Wheel down, clears my focus.

I have mouse activated (repeater region) for the DK's: AMS, PoF, IBF, Lichborne, Pet, and Army.
I have mouse activated (repeater region) for the Pally: Big Button 1 (all cooldowns, except bubble), Big Button 2 (as #1, but no Aura Mastery), Aura Mastery, Divine Plea, Divine Shield, Lay on Hands, Hand of Protection.

So, a few more than two keys on the Pally.
But a lot of the stuff is automated by being built into keys that I spam constantly anyway.