Set your page file to a static value, no range. Put the page file on its own HD by itself, if possible. If it shares with other files/folders, the static value helps prevent it from becoming fragmented if it happens to increase in size.
You can set a local policy to clear the pagefile out, but that is only if you're overly paranoid about security.

Some apps page whether you have gobs of memory or not, does WoW? No idea, you would have to set up perf counters and find out. I would recommend against removing the pagefile as a whole, though.