Does anyone know if there is a quick way to change my keybind layouts?

For example, when I am PvPing on my hunter solo there's a lot of abilities I want handy that are absolutely useless when I am multiboxing doing PvE or whatever.

Will Dominos change all that with profiles or is the info kept server-side?

FWIW, I'm on a Mac - please no "ISBoxer does it" answers or whatever .