1. FAQ: I am using a mouse button as a hotkey for something, and sometimes it doesn't work, what am I doing wrong?

2. You said you cant set them as hotkeys... but you didn't mention what exactly is stopping you. Why can't you? Does the button not show up in the box when you click in the "press key here" box? Is it not in the drop-down box? Where are you setting them? Do you get an error message when you launch ISBoxer, that you're not mentioning?