Take my recent two setups.

One was 5x Resto Druids.
I have the same key for follow, and use similar keys for DPS.
1 is an attack.
2 is another attack.
7,8,9,0 are targeted heals.

In that regard, the team is consistent with every other team I've ever played.

The click based heals (are a similar mechanic), but the clicks were much more so.
For a typical team I have 2-4 clicks to learn.
For the Druids (who were all healer spec), I had 13 clicks to learn.

I started off with:
Left Click = Rejuvenation
Right Click = Nourish

And added other heals over time.
Rather had all of them configured, but forced myself to also do Scroll Wheel Up over and over for a few Battlegrounds.
Until that was "learnt".






I had previously played my 4x Death Knight, 1x Paladin team.
Quite a lot... because they had over 20,000 honor kills on each already.

The basics were still the same.
Target something with the healer (their mouse clicks whatever).
And spam "1".

But the hotkeys or specials took a while to re-learn, although I had "known" them intimately for over a year a couple years back.
Things like:
- Anti-Magic Shell
- Lichborne
- Summon Pet
- Pillar of Frost

Adding those and getting used to clicking one (that prevents a knockback effect from moving me), when I see a Druid or Shaman running at me while I'm on a ledge.
And they still get me, but I negate their ability often, by pressing Shift + K, or clicking that ability in time...
And then kill them rather easily, now that they're a caster in melee.

Ditto on Lichborne, when a Priest or Warlock runs at my group.
I will target them, and attack with the DK's... who because of IWT... will run at the person.
My healer runs away, to get out of the AoE.
And I use Shift F, to negate the fear (and sleep/charm).
And kill the pesky fear class quickly.
But it is also a learning process.



The DK's have Strangulate.
Which requires facing (which isn't always there).
I've set up my key for Focus.
DK's A & B, Focus on Press 1, of my key "0" (which is far enough over, to not accidently push it).
DK's C & D, Focus on Press 2, of the same key.
With a delay in there, so I cannot accidently spam it.
It is actually set up, so the appropriate toons assist me on Push down.
And Focus on release of the key.
So I can push and hold it, to account for latency, etc.

Strangulate is another hotkey, which will be spammed sort of.
Because of IWT, my toons are circling about their targets quickly.
And will likely be facing their Focus target (who will be Strangulated at the key press) at least some of the time.
I have it set up to not advance until "x" time after my most recent press.
So I can spam it a few times, as I spam my IWT.
And on the initial spam:
DK's A & C, each Strangulate their target.
On the second set of spam presses, it is DK's: B & D.

In an ideal world:
- A/B focus Healer one.
- C/D focus Healer two.

And on Presses:
Press 1 - A Strangulates Healer one; C strangulates Healer two.
Press 2 - B Strangulates Healer one; D strangulates Healer two.

So two different targets are both strangulated, one after the other.

It takes a while to add the tool to the arsenal, and to get used to it.
Eventually it is second nature.




If I went back to the Druids (as Resto), they're a new team again.
I'd pick them up much faster, but they'd be new for a short while.

Meanwhile my other teams have not been played in a long time.
They're still 80th, meaning they have not made a Cataclysm debut yet.
So I'll have to configure them (similar in the basic mode to other teams), to get them how I like.
And then will have to "learn" them again too.
If I'm just leveling, I won't go fancy like Strangulate or AMS/Lichborne/Pillar/IceboundFortitude etc...