It would work. The thing is you wouldn't really have time to drain the mobs. I'm not sure about whether or not Shadow EMbraces from different locks stack. I would guess not. So you would get up to 6 affliction effects easily that way, then siphon life, and the drain life is counted in the boost too. So there's at least 12 affliction effects on the mobs when they start dying. That is a lot of extra damage.