From the isboxer.com forums...

Known issues:
* Window Layouts with Instant Swapping will not work correctly. Disable it.
* Your Key Maps may require the Hold option, especially if they include a modifier (Alt, Shift, or Ctrl)
* You cannot launch multiple instances of the LAUNCHER, just the GAME. This is intended behavior and is pretty much the same for all games; the next launcher will come up after the game is successfully launched and the first launcher goes away.
* If you have multiple monitors with different resolutions, you may need Inner Space build 5501 or later, and make sure the game is in Windowed mode (in the game) rather than Fullscreen mode -- see http://isboxer.com/forum/viewtopic.php?p=7407#p7407 for details