Well I can imagine having (on lets say 378 gear levels) chain lightning replacing light bolt is more convenient as it's a small dps increase single target (provided you don't go oom), but also works on trash packs. Not sure what the easiest to pve box is, but there are quite some 3+ mob trash packs in the new heroics that you want to kill asap, so glyphing CL is a good thing. How would you manage the 30% mana mark then? Either way, glyphed CL and use it as a single target spell is quite a dps loss.
I personally would go with a single target macro that spams lightning bolt, use a full fulmination stack now and then, and . use lava burst whenever it's off CD (if you have 2p T12 from justice points, the Fire Elemental cooldown will only be reduced by bolts). And have a dedicated button to spam chain lightning only on trash. It's so unbelievably good since they removed the CD that it's one of the most powerful aoe's in the game. And on really big trash packs, multiple Earthquakes combined with CL is just crazy. Don't bother with fire totems, flame shock spreading or EQ, basically just spam Chain lightning and everything will drop).
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