No it's not a macro, it's just the spell icon (I keep 3 buffs on hotkeys only and just hit F1 to cast the blessings on my paladin, and F3-F5 for the mages).

Setup is this

Computer A (Main, Single Client (Paladin Tank))
Computer B (Secondary, Single Client (Paladin Healer))
Computer C (Tertiary, Three Clients (Mages))

Computer A and B are linked via network connection. I will use the pause override to respond to tells and such and this seems to trigger the problem most frequently, but I've notice it occur when i'm just slamming my healing buttons really fast (I'm a masher, MASHER I SAY)
Computer C is not connected to A/B at all, but almost never uses the override button since I don't respond to tells, etc. on them

So when the problem occurs I can alt-tab the healer system out and back in, and both problems go away until it happens again.