i have 2 cards, non sli, mon1 to main and mon2/card2 to slaves. in wow i have the primary display on slaves set to mon2. i do cross monitor switching and there is sometimes a bit of delay but for the most part no perf dercrease or fps loss other than that initial second. its important though that you have your clients set to the right default monitor. it kinda looks weird when you launch and the slave clients start on 2nd display, bounce to main, resize to their home on 2nd. but that gave me the biggest boost in performance was making the clients set to the right monitor.
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