@Apps:
I don't understand how the presence or absence of macros makes hardware boxing easier than software. I spent two hours working in ISBoxer and got a setup that should work fine for PvE:

I have an individual keymap for each character. When that character gets pip swapped to it activates his map and deactivates the others. Each map has a unique "target partyX" and "assist partyX" bound in game. Then, every button that needs an assist has two steps; One step sends the unique "assist partyX" and the next step sends the keypress. Each of these activates on keypress down or up, so you can just spam the button.

It's not elegant but it's about the best that can be done without macros. It breaks down in BG's where you may or may not get to reorder your characters properly.

As long as multiple instances can be opened on one PC we're golden now... And I'm sure Lax can or has already included an option that will force games to open.