I usually set view to max on main, minimum to medium on slaves, all detail to lowest, and resolution to somewhere around 1080p x 720p. I enable particle density on my main cause I like to see the rippling effect of Concecrate, Blood Boil, and the like.

I have a i7 2600k processor, 16 gig ram, GTX 550ti Nvidia card, SSD 120gig drive for wow and windows.

this handles 5 wows like creamy butter, so a similar rig like yours could easily run with graphics similar or even better with 10 wow's.