This is actually very easy to set up with inner space. Inside inner space you can set up configurations for graphic cards. I have 3 monitors and 2 graphic cards. The main monitor has one card and the other 2 monitors share the other card. In ISboxer I created a 5 screen layout that allowed screen swapping. I did all this about 2 years ago. I forgot exactly what I had done so I am no help there. I kept the configurations and they work fine today. In fact inner space and isboxer are both very stable and probably the best in stability in my experience. I think the winning combination for ease of use and setup for multi-boxing is inner space + isboxer + jamba.
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