Seeking Input on New 5-Boxing Build

[RSM72]

Running the alts from separate drives will actually increase memory usage and load on your system because windows will try to cache the game client 5 times while with one shared client It will be loading most stuff from cache once the first client is in memory. 4x separate SSD cant beat loading stuff from cache or ramdisk.

Also SLI will most likely give you more headaches then performance improvements so unless you really need those cards to power your 4 screens its better to go for a 3GB 580 (I'd probably go with 2x 30 inch if money wasnt an issue).

EDIT: btw I'm running your intended setup on a sturdy i7 920 (3.6Ghz) with a single gtx580 (upgraded to 3G but 1.5G worked too) from a single SSD at 55-60 fps (main) / 30 fps (slaves) on two 24 inch screens