Wait for the sandy bridge e release. The current 2600k is a great chip but the chipsets are not as powerful as the X58 currently. The update for this is due end of this year. Will have quad channel memory instead of tri channel with up to 40 PCI Express lanes for multi GPU goodness (I am assuming from the plural of 460s that you are looking at MultiGPU). If you really want something now then I would say go the 2600k direction as you mention the most effective option fo the next few years and hopefully the sandy bridge chipsets will accept a CPU upgrade or two if you so choose.