Any of ISBoxer's in-game widgets will help you on your quest to click.

Click Bars will let you set up anything you want as clickable buttons, so long as you are willing to figure out how to map them
Repeater Regions will let you automatically broadcast clicks over certain regions, like if you wanted to just click on some icon in the game and have it go to everyone
Video FX will let you make live interactive views of all or parts of other windows, if you are using Windows Vista or later, with Aero enabled

Yes, a lot of the tutorials that people have made are from WoW players, but the process of setting up a Repeater Region, a Click Bar, or Video FX is no different from game to game. FTL is for auto-assisting, you can leave that part out of whatever you're configuring. The only thing that is different from EQ1 to EQ2 to RIFT to WoW is what keys each window can press to do what in the game.