Quote Originally Posted by riffraff View Post
You may be doing this already but if not...

Don't assign skills you are going to be using over and over to the thumb buttons. Use stuff like CC, PVP trinkets, etc. once-in-a-while skills. I think any skill you would be hammering over and over would indeed make your thumb very tired if assigned to these buttons.
/care about sore tumbz?! We need 2,2k rating